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Symbol
Name
ID 		Stat1
signal transducer and activator of transcription 1
MGI:103063
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Autoimmune hemolytic anemia
Neutropenia in presence of anti-neutropil antibodies
B lymphocytopenia
T lymphocytopenia
Lymphopenia
Autoimmune thrombocytopenia
Recurrent upper respiratory tract infections
Hepatosplenomegaly
Enterocolitis
Hepatitis
Thyroiditis
Abnormal circulating interferon-gamma concentration
Inflammatory abnormality of the skin
Eczematoid dermatitis
Chronic mucocutaneous candidiasis
Antiphospholipid antibody positivity
Immune dysregulation
Immunodeficiency
BCGitis
Recurrent infections
Recurrent mycobacterial infections
Recurrent mycobacterium avium complex infections
Recurrent Aspergillus infections
Recurrent viral infections
Herpes simplex encephalitis
Infectious encephalitis
Recurrent herpes
Disease(s) Associated with STAT1
immunodeficiency 31A
immunodeficiency 31B
immunodeficiency 31C

Mouse Phenotypes
immune system phenotype
abnormal osteoclast differentiation
decreased NK cell degranulation
peritoneal inflammation
abnormal T cell differentiation
abnormal CD4-positive T cell differentiation
abnormal CD8-positive, alpha-beta T cell differentiation
increased basophil cell number
increased eosinophil cell number
increased neutrophil cell number
decreased B-1 B cell number
decreased B cell number
decreased NK cell number
increased effector memory CD4-positive, alpha-beta T cell number
increased CD4-positive, alpha-beta T cell number
increased effector memory CD8-positive, alpha-beta T cell number
abnormal CD8-positive, naive alpha-beta T cell number
decreased CD8-positive, naive alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
increased NK T cell number
decreased single-positive T cell number
increased T cell number
decreased lymphocyte cell number
increased lymphocyte cell number
increased large unstained cell number
increased osteoclast cell number
increased monocyte cell number
increased leukocyte cell number
abnormal leukocyte physiology
increased IgG level
abnormal NK cell physiology
impaired natural killer cell mediated cytotoxicity
abnormal T-helper 2 physiology
decreased cytotoxic T cell cytolysis
abnormal T cell activation
abnormal macrophage physiology
abnormal MHC II cell surface expression on macrophages
increased macrophage nitric oxide production
decreased circulating interferon-gamma level
increased circulating interferon-gamma level
increased circulating interleukin-12b level
enlarged lymph nodes
decreased level of surface class I molecules
decreased interferon-gamma secretion
decreased interleukin-1 beta secretion
decreased susceptibility to endotoxin shock
lung inflammation
bronchiolitis
pleuritis
abnormal response to infection
increased susceptibility to bacterial infection
increased susceptibility to bacterial infection induced morbidity/mortality
increased susceptibility to Coronaviridae infection induced morbidity/mortality
increased susceptibility to Herpesvirales infection
increased susceptibility to Coronaviridae infection
increased susceptibility to Togaviridae infection
increased susceptibility to Riboviria infection
Availability Mouse Genotype
Stat1fae/Stat1fae
Stat1m1Anu/Stat1m1Anu
Stat1m1Btlr/Stat1m1Btlr
Stat1m2Btlr/Stat1m2Btlr
Stat1m3Btlr/Stat1m3Btlr
Stat1m4Btlr/Stat1m4Btlr
Stat1m5Btlr/Stat1m5Btlr
Stat1tm1Dlv/Stat1tm1Dlv *
Stat1tm1Rds/Stat1tm1Rds
Stat1tm1Tdec/Stat1tm1Tdec
Stat1tm1Uvin/Stat1tm1Uvin
Stat1tm2.1Uvin/Stat1tm2.1Uvin *
Stat1tm2b(EUCOMM)Wtsi/Stat1tm2b(EUCOMM)Wtsi
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory